https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38853 r = 0.3–0.5; P ≤ 0.05). Total ARCS predicts cognitive impairment with good sensitivity and specificity relative to the BICAMS tests (AUC = 0.8; P = 0.00045). Total ARCS detects higher levels of impairment than BICAMS in MS patients (44% versus 21%). The memory domain of the ARCS and the BVMT-R were the best predictors of employment status (OR = 1.12 and 1.14, P  < 0.05). Conclusion: BICAMS and ARCS have comparable sensitivity for cognitive impairment in MS. Memory assessment from either tests is the best predictor of employment status; however, the BICAMS is a better predictor of work productivity.]]> Wed 23 Nov 2022 15:41:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33281 Tue 25 Sep 2018 11:08:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53309 .05). Compared to HCs, both RRMS cohorts showed volume changes in white matter (−13%), gray matter (−16%), and cerebral spinal fluid (CSF) (+17-23%), as well as reduced NAA (−17%, p =.001, hippocampus), (−7%, p =.001, PCG), and (−9%, p =.001, PFC). MRI/S metrics in three regions were moderately correlated with cognition and fatigue functions. Conclusion: While both treatment arms showed overall similar volumetric and neurometabolic profiles, longitudinal studies are warranted to clarify neurometabolic changes and associations with treatment efficacy.]]> Tue 21 Nov 2023 12:02:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44317 Tue 11 Oct 2022 16:19:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36572 Tue 09 Jun 2020 11:40:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39917 Thu 30 Jun 2022 11:48:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31520 Sat 24 Mar 2018 08:43:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42377 Mon 22 Aug 2022 14:29:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43429 P ≤ .05). Only GPC showed positive correlation with all fatigue domains (r = .537, P ≤ .05). On the other hand, Glx-upper, NAA-2, GSH+Hca, and fucose-3 showed negative correlations with all fatigue domains (r = –.345 to –.580, P ≤ .05). While tyrosine showed positive correlation with MFIS (r = .499, P ≤ .05), cognitive fatigue was negatively correlated with total GSH (r = –.530, P ≤ .05). No correlations were found between lesion load or brain volumes with fatigue score. CONCLUSIONS: Our results suggest that fatigue in MS is strongly correlated with an imbalance in neurometabolites but not structural brain measurements.]]> Mon 19 Sep 2022 09:29:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30630 1H-MRS) and localization techniques principles, different fast MRSI techniques will be discussed from their initial development to the recent innovations with particular emphasis on their capacity to record neurochemical changes in the brain in a variety of pathologies. The clinical applications of whole brain fast spectroscopic techniques, can assist in the assessment of neurochemical changes in the human brain and help in understanding the roles they play in disease. To give a good example of the utilities of these techniques in clinical context, MRSI application in multiple sclerosis was chosen. The available up to date and relevant literature is discussed and an outline of future research is presented.]]> Mon 11 Mar 2019 12:08:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36797 Mon 06 Jul 2020 16:25:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47726 Fri 24 Feb 2023 14:56:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47224 Fri 16 Dec 2022 10:37:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30423 Fri 03 Dec 2021 10:34:50 AEDT ]]>